NFL Week 4 Lines, Predictions & SNF Inactives

This is our guide to Week 4 in the NFL – you can click here for all the intel on Week 5.

We are on to a terrific slate of Sunday Week 4 games in the NFL and we have everything you need, including latest lines, odds, picks, predictions, TV details and those all-important inactives.

We have some fantastic matchups in prospect, including Jacksonville visiting Philadelphia, Buffalo facing off with Baltimore and Tom Brady vs Patrick Mahomes down in Florida.

We have the latest lines for you, plus a host of picks and predictions (and some nice signup bonus offers).

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NFL Predictions & Picks for Week 4

We have a ton of picks and predictions for you, and here is how you can get them:

We have NFL picks against the spread for every single Sunday game

Want the best NFL Parlay Picks? Look no further for a 4-way, +1105 play (we hit on a 6-leg, SGP when Cincinnati defeated Miami on Thursday Night Football).

If NFL prop bets are your thing, you’ll want to check out these little beauties

Kansas City vs Tampa Bay is a mouthwatering matchup on Sunday Night Football and we have picks.

Jets fan? We have the latest on all the odds for the green half of New York, and picks for that early afternoon visit to Pittsburgh.

Love the Giants? Again we have all the latest odds intel on Big Blue plus picks for the 1pm kickoff at home to the Chicago Bears.

Hi there Dallas Cowboys Nation, we have you covered too with all the latest from the Metroplex, plus some predictions and picks for Sunday’s showdown with Washington at JerryWorld.

And last but absolutely not least, our overall predictions and picks for that Los Angeles Rams/San Francisco 49ers showdown on MNF.

NFL Week 4 Lines, Start Times & TV Details

Here are the very latest lines and spreads heading into Sunday’s slate:

Sunday October 2, 2022

New Orleans Saints (+3.5) vs Minnesota Vikings (-3.5) (Tottenham) 9:30 AM NFLN

Cleveland Browns (-1) at Atlanta Falcons (+1) 1:00 PM CBS

Los Angeles Chargers (-5.5) at Houston Texans (+5.5) 1:00 PM CBS

Chicago Bears (+3) at New York Giants (-3) 1:00 PM FOX

Arizona Cardinals (+1) at Carolina Panthers (-1) 1:05 PM FOX

Seattle Seahawks (+3.5) at Detroit Lions (-3.5) 1:00 PM FOX

Tennessee Titans (+3.5) at Indianapolis Colts (-3.5) 1:00 PM FOX

New York Jets (+3.5) at Pittsburgh Steelers (-3.5) 1:00 PM CBS

Buffalo Bills (-3) at Baltimore Ravens (+3) 1:00 PM CBS

Jacksonville Jaguars (+6.5) at Philadelphia Eagles (-6.5) 1:00 PM CBS

Washington Commanders (+3) at Dallas Cowboys (-3) 1:00 PM FOX

Denver Broncos (+2.5) at Las Vegas Raiders (-2.5) 4:25 PM CBS

New England Patriots (+9.5) at Green Bay Packers (-9.5) 4:25 PM CBS

Kansas City Chiefs (+1) at Tampa Bay Buccaneers (-1) 8:20 PM NBC

Monday October 3, 2022

Los Angeles Rams (+1.5) at San Francisco 49ers (-1.5) 8:15 PM ESPN

NB: All lines correct on Sunday October 2, 2022

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NFL Week 4 Inactives

If you are betting or playing fantasy, you will need these:

Los Angeles Rams

QB Bryce Perkins
WR Tutu Atwell
C Brian Allen
OL David Edwards
CB Cobie Durant
CB David Long
DB Shaun Jolly

San Francisco 49ers

RB Ty Davis-Price
WR Danny Gray
TE Tyler Kroft
OT Trent Williams
OL Nick Zakelj
DT Javon Kinlaw
S Tarvarius Moore

Kansas City Chiefs

RB Ronald Jones
K Harrison Butker
QB Shane Buechele
DE Mike Danna
T Darian Kinnard
DE Benton Whitley
DE Joshua Kaindoh

Tampa Bay Buccaneers

QB Kyle Trask
TE Kyle Rudolph
WR Scotty Miller
WR Breshad Perriman
CB Zyon McCollum
DL Akiem Hicks

Minnesota Vikings

OT Vederian Lowe
OL Chris Reed
DL Esezi Otomewo
OLB Luiji Vilain
CB Andrew Booth Jr.

New Orleans Saints

QB Jameis Winston
RB Tony Jones Jr.
RB Alvin Kamara
WR Michael Thomas
TE Nick Vannett
G Andrus Peat
S Marcus Maye

Cleveland Browns

QB Kellen Mond
WR Michael Woods II
T Joe Haeg
T Chris Hubbard
DE Jadeveon Clowney
DE Myles Garrett
DT Taven Bryan

Atlanta Falcons

LB Nick Kwiatkoski
LB Quinton Bell
OL Chuma Edoga
WR Jared Bernhardt
WR Bryan Edwards
DL Matt Dickerson

Buffalo Bills

WR Jake Kumerow
TE Tommy Sweeney
OL Justin Murray
DT Jordan Phillips
DT Ed Oliver
CB Christian Benford

Baltimore Ravens

OT Ronnie Stanley
OL Patrick Mekari
OLB Justin Houston
CB Jalyn Armour Davis
RB Kenyan Drake

Washington Commanders

QB Sam Howell
CB Tariq Castro-Fields
G Chris Paul
TE Cole Turner
DT Daniel Wise

Dallas Cowboys

QB Dak Prescott
S Jayron Kearse
WR Jalen Tolbert
LB Devin Harper
T Matt Waletzko
CB Nahshon Wright

Seattle Seahawks

CB Artie Burns
CB Justin Coleman
S Joey Blount
G Phil Haynes
WR Dareke Young
DT Myles Adams

Detroit Lions

DL John Cominsky
WR DJ Chark
G Jonah Jackson
K Austin Seibert
WR Amon-Ra St.Brown
RB D’Andre Swift
DL Demetrius Taylor

Los Angeles Chargers

QB Easton Stick
WR Keenan Allen
S JT Woods
RB Isaiah Spiller
TE Donald Parham Jr.
DT Otito Ogbonnia

Houston Texans

TE Brevin Jordan
DB Issac Yiadom
LB Jake Hansen
DL Michael Dwumfour
OL Austin Declus
TE Pharaoh Brown
DL Demone Harris

Tennessee Titans

OL Le’Raven Clark
LB Wyatt Ray
LB Ola Adeniyi
DB Ugo Amadi
LB Zach Cunningham
DB Amani Hooker
DB Theo Jackson

Indianapolis Colts

S Julian Blackmon
QB Sam Ehlinger
CB Dallas Flowers
C Wesley French
WR Dezmon Patmon
OT Luke Tenuta
DT Chris Williams

Chicago Bears

K Cairo Santos
DB Dane Cruikshank
RB David Montgomery
DB Jaylon Johnson
LB Matt Adams
OL Ja’Tyre Carter
TE Ryan Griffin

New York Giants

CB Cor’Dale Flott
CB Nick McCloud
WR Wan’Dale Robinson
WR Kadarius Toney
DL Leonard Williams
ILB Austin Calitro
OT Tyre Phillips

Jacksonville Jaguars

WR Zay Jones
WR Kendric Pryor
RB Snoop Conner
S Tyree Gillespie
CB Montaric Brown
OLB K’Lavon Chaisson
OL Cole Van Lanen

Philadelphia Eagles

QB Ian Book
CB Avonte Maddox
S Reed Blankenship
RB Boston Scott
DE Janarius Robinson
G Josh Sills

New York Jets

QB Mike White
TE Lawrence Cager
OL Cedric Ogbuehi
LB Quincy Williams
S Will Parks
WR Denzel Mims
CB Bryce Hall

Pittsburgh Steelers

QB Mason Rudolph
CB Ahkello Witherspoon
G Kendrick Green
WR Steven Sims
DT Isaiahh Loudermilk
LB Mark Robinson
LB David Anenih

Arizona Cardinals

WR A.J. Green
LB Ezekiel Turner
LB Jessie Luketa
RB Keaontay Ingram
LB Myjai Sanders
OL Lecitus Smith
DL Rashard Lawrence

Carolina Panthers

RB Raheem Blackshear
CB Stantley Thomas-Oliver
OL Cade Mays
DT Phil Hoskins
WR Terrace Marshall Jr.
DE Amaré Barno

New England Patriots

QB Mac Jones
CB Jalen Mills
WR Jakobi Meyers
DE Lawrence Guy
DB Joshuah Bledsoe

Green Bay Packers

CB Jaire Alexander
T Rasheed Walker
G/T Sean Rhyan
WR Samori Toure
DL Jonathan Ford

Denver Broncos

WR Jalen Virgil
WR Tyrie Cleveland
CB Darius Phillips
OLB Jonathon Cooper
OL Billy Turner
G/C Quinn Meinerz
DL Eyioma Uwazurike

Las Vegas Raiders

WR Hunter Renfrow
S Rock Ya-Sin
RB Brittain Brown
G John Simpson
TE Foster Moreau
DT Neil Farrell Jr.
DE Tashawn Bower