NFL Week 5 Lines, Picks, Predictions & Inactives

We are on to a terrific slate of Sunday Week 5 games in the NFL and we have everything you need, including latest lines, odds, picks, predictions, TV details and those all-important inactives.

We have some fantastic matchups in prospect, including a key AFC North matchup with Cincinnati visiting Baltimore and the Dallas Cowboys locking horns with the Super Bowl champion Rams in Los Angeles.

We have the latest lines for you, plus a host of picks and predictions (and some nice signup bonus offers).

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NFL Predictions & Picks for Week 5

We have a ton of picks and predictions for you, and here is how you can get them:

We have NFL picks against the spread for every single Sunday game

Want the best NFL Parlay Picks? Look no further for a 4-way, +1348 play.

If NFL prop bets are your thing, you’ll want to check out these little beauties

Cincinnati vs Baltimore is a mouthwatering matchup on Sunday Night Football and we have picks.

Jets fan? We have the latest on all the odds for the green half of New York, and picks for that home game vs the Miami Dolphins.

Love the Giants? Again we have all the latest odds intel on Big Blue plus picks for the Sunday showdown with Aaron Rodgers and the Packers in London.

Hi there Dallas Cowboys Nation, we have you covered too with all the latest from the Metroplex, plus some predictions and picks for Sunday’s big game vs the Rams in L.A.

And last but absolutely not least, our overall predictions and picks for that Las Vegas vs Kansas City showdown on MNF.

NFL Week 5 Lines, Start Times & TV Details

Here are the very latest lines and spreads heading into Sunday’s slate:

Week 5

Thursday October 6, 2022

Indianapolis Colts 12-9 Denver Broncos (OT) 8:15 PM Prime Video

Sunday October 9, 2022

New York Giants (+8) vs Green Bay Packers (-8) (Tottenham) 9:30 AM NFLN

Los Angeles Chargers (-2.5) at Cleveland Browns (+2.5) 1:00 PM CBS

Houston Texans (+7) at Jacksonville Jaguars (-7) 1:00 PM CBS

Atlanta Falcons (+9.5) at Tampa Bay Buccaneers (-9.5) 1:00 PM FOX

Pittsburgh Steelers (+14) at Buffalo Bills (-14) 1:00 PM CBS

Chicago Bears (+7.5) at Minnesota Vikings (-7.5) 1:00 PM FOX

Detroit Lions (+3) at New England Patriots (-3) 1:00 PM FOX

Seattle Seahawks (+5.5) at New Orleans Saints (-5.5) 1:00 PM FOX

Tennessee Titans (-1.5) at Washington Commanders (+1.5) 1:00 PM CBS

Miami Dolphins (-3) at New York Jets (+3) 1:00 PM CBS

San Francisco 49ers (-6.5) at Carolina Panthers (+6.5) 4:05 PM CBS

Philadelphia Eagles (-5) at Arizona Cardinals (+5) 4:25 PM FOX

Dallas Cowboys (+5.5) at Los Angeles Rams (-5.5) 4:25 PM FOX

Cincinnati Bengals (+3.5) at Baltimore Ravens (-3.5) 8:20 PM NBC

Monday October 10, 2022

Las Vegas Raiders (+7) at Kansas City Chiefs (-7) 8:15 PM ESPN

NB: All lines correct on Friday October 7, 2022

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NFL Week 5 Inactives

If you are betting or playing fantasy, you will need these:

Cincinnati Bengals

RB Trayveon Williams
OT D’Ante Smith
G Jackson Carman
CB Cam Taylor-Britt
DT Jay Tufele

Baltimore Ravens

WR Rashod Batement
RB Justice Hill
CB Jayln Armour-Davis
OLB Justin Houston
LB A.J. Klein
G Ben Cleveland

San Francisco 49ers

RB Marlon Mack
DT Arik Armstead
DT Javon Kinlaw
LT Trent Wiliams
RB Ty Davis-Price
S Tarvarius Moore
TE Tyler Kroft

Carolina Panthers

WR Laviska Shenault
WR Rashard Higgins
CB Stantley Thomas-Oliver
S Xavier Woods
LB Frankie Luvu
OL Cade Mays
TE Stephen Sullivan

Philadelphia Eagles

K Jake Elliott
QB Ian Book
CB Avonte Maddox
LB Patrick Johnson
DE Janarius Robinson
T Jordan Mailata

Arizona Cardinals

K Matt Prater
CB Trayvon Mullen
RB Keaontay Ingram
LB Jesse Luketa
C Rodney Hudson
OL Max Garcia
DL Rashard Lawrence

Dallas Cowboys

QB Dak Prescott
T Jason Peters
WR Jalen Tolbert
DT Quinton Bohanna
S Markquese Bell
LB Devin Harper
CB Nahshon Wright

Los Angeles Rams

CB David Long
S Taylor Rapp
WR Lance McCutcheon
C Brian Allen
CB Cobie Durant
QB Bryce Perkins

Pittsburgh Steelers

QB Mason Rudolph
DB Ahkello Witherspoon
S Terrell Edmunds
G Kendrick Green
WR Gunner Olszewski
DT Isaiahh Loudermilk
LB Mark Robinson

Buffalo Bills

WR Isaiah McKenzie
WR Jake Kumerow
TE Dawson Knox
OL Justin Murray
LB Tremaine Edmunds
CB Christian Benford
S Jordan Poyer

Los Angeles Chargers

WR Keenan Allen
K Dustin Hopkins
QB Easton Stick
RB Isaiah Spiller
S JT Woods
TE Richard Rodgers
DT Otito Ogbonnia

Cleveland Browns

QB Kellen Mond
WR Michael Woods II
RB Demetric Felton Jr.
T Joe Haeg
G Drew Forbes
T Chris Hubbard
TE Miller Forristall

Houston Texans

TE Brevin Jordan
WR Chris Moore
DL Jonathan Greenard
LB Blake Cashman
DL Thomas Booker
OL Austin Deculus
DL Demone Harris

Jacksonville Jaguars

WR Kendric Pryor
RB Snoop Conner
S Tyree Gillespie
CB Montaric Brown
OLB De’Shaan Dixon
DL Folorunso Fatukasi

Chicago Bears

DB Dane Cruikshank
DL Kingsley Jonathan
DB Jaylon Johnson
TE Jake Tonges

Minnesota Vikings

CB Andrew Booth Jr.
OLB Luiji Vilain
G/C Chris Reed
T Vederian Lowe
WR Jalen Nailor
DL Esezi Otomewo
DL Khyiris Tonga

Detroit Lions

CB Amani Oruwariye
WR DJ Chark
RB D’Andre Swift
DL Charles Harris
DL John Cominsky
S JuJu Hughes
T Matt Nelson

New England Patriots

DT Lawrence Guy
DE DaMarcus Mitchell
QB Mac Jones
TE Jonnu Smith
DB Joshuah Bledsoe
CB Shaun Wade
RB Pierre Strong

Seattle Seahawks

WR Marquise Goodwin
CB Sidney Jones IV
CB Justin Coleman
S Teez Tabor
T Jake Curhan
WR Dareke Young

New Orleans Saints

WR Jarvis Landry
S Marcus Maye
WR Michael Thomas
G Calvin Throckmorton
DE Payton Turner
TE Nick Vannett
QB Jameis Winston

Miami Dolphins

QB Tua Tagovailoa
RB Salvon Ahmed
WR Erik Ezukanma
TE Hunter Long
CB Xavien Howard
LB Trey Flowers

New York Jets

QB Mike White
WR Denzel Mims
TE Lawrence Cager
LB Quincy Williams
CB Bryce Hall
S Tony Adams

Atlanta Falcons

TE Kyle Pitts
LB DeAngelo Malone
LB Nick Kwiatkoski
OL Chuma Edoga
WR Jared Bernhardt

Tampa Bay Buccaneers

QB Kyle Trask
WR Julio Jones
WR Breshad Perriman
TE Cameron Brate
S Logan Ryan
DL Akiem Hicks

Tennessee Titans

DB Ugo Amadi
S Amani Hooker
LB Zach Cunningham
LB Joe Jones
OLB Bud Dupree
G Nate Davis
OLB Ola Adeniyi

Washington Commanders

WR Jahan Dotson
QB Sam Howell
S Percy Butler
CB Tariq Castro-Fields
LB David Mayo
T Sam Cosmi
TE Logan Thomas

New York Giants

QB Tyrod Taylor
WR Kenny Golladay
WR Wan’Dale Robinson
WR Kadarius Toney
OLB Azeez Ojulari
CB Cor’Dale Flott
DL Leonard Williams

Green Bay Packers

WR Samori Toure
OT Rasheed Walker
OL Sean Rhyan
DL Jonathan Ford
DL Devonte Wyatt

Indianapolis Colts

QB Sam Ehlinger
RB Jonathan Taylor
OT Luke Tenuta
C Wesley French
DE Tyquan Lewis
LB Shaquille Leonard
S Julian Blackmon

Denver Broncos

RB Latavius Murray
WR Jalen Virgil
OL Quinn Meinerz
OLB Jonathon Cooper
OLB Aaron Patrick
CB Darius Phillips
S P.J. Locke